TABLE 2.
Association of brain levels of α‐ and γ‐tocopherol with microglia density by brain region
| Microglia stage I/II/III | Microglia stage II/III | Microglia stage III | ||||||
|---|---|---|---|---|---|---|---|---|
| Tocopherols | Brain region | Model | B (SE) | P | B (SE) | P | B (SE) | P |
| α‐Tocopherol | Cortical | Basic‐adjusted a | –0.25(0.09) | .01 | –0.20(0.10) | .04 | –0.19(0.09) | <.05 |
| +AD pathology b | –0.20(0.09) | .03 | –0.10(0.09) | .25 | ‐0.09(0.09) | .28 | ||
| α‐Tocopherol | Subcortical | Basic‐adjusted a | 0.11(0.10) | .26 | 0.12(0.09) | .20 | 0.04(0.09) | .69 |
| +AD pathology b | 0.11(0.10) | .28 | 0.12(0.09) | .20 | 0.04(0.09) | .69 | ||
| γ‐Tocopherol | Cortical | Basic‐adjusted a | –0.25(0.10) | .01 | –0.25(0.10) | .01 | –0.25(0.10) | .01 |
| +AD pathology b | –0.15(0.10) | .16 | –0.07(0.09) | .48 | ‐0.07(0.09) | .45 | ||
| γ‐Tocopherol | Subcortical | Basic‐adjusted a | –0.01(0.10) | .89 | 0.004(0.09) | .96 | –0.01(0.09) | .96 |
| +AD pathology b | –0.03(0.10) | .79 | 0.02(0.09) | .86 | 0.02(0.09) | .80 | ||
The association magnitudes (B) are reported in SD (±SE) change in microglia density per 1 SD increase in tocopherol concentration. Microglia stages I to III represent different stages of microglia activation, microglia density scores were calculated for total count (stage I/II/III), activated microglia (stage II/III), and macrophages (stage III).
SE, standard error.
a
Basic model adjusted for age at death (years), sex, education (years), APOE ε4 (any ε4 vs none) and post‐mortem autopsy time (hours.
b
Basic model +amyloid load and neurofibrillary tangle severity (Braak score).