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. 2020 Aug 24;6(1):e12021. doi: 10.1002/trc2.12021

TABLE 2.

Association of brain levels of α‐ and γ‐tocopherol with microglia density by brain region

Microglia stage I/II/III Microglia stage II/III Microglia stage III
Tocopherols Brain region Model B (SE) P B (SE) P B (SE) P
α‐Tocopherol Cortical Basic‐adjusted a –0.25(0.09) .01 –0.20(0.10) .04 –0.19(0.09) <.05
+AD pathology b –0.20(0.09) .03 –0.10(0.09) .25 ‐0.09(0.09) .28
α‐Tocopherol Subcortical Basic‐adjusted a 0.11(0.10) .26 0.12(0.09) .20 0.04(0.09) .69
+AD pathology b 0.11(0.10) .28 0.12(0.09) .20 0.04(0.09) .69
γ‐Tocopherol Cortical Basic‐adjusted a –0.25(0.10) .01 –0.25(0.10) .01 –0.25(0.10) .01
+AD pathology b –0.15(0.10) .16 –0.07(0.09) .48 ‐0.07(0.09) .45
γ‐Tocopherol Subcortical Basic‐adjusted a –0.01(0.10) .89 0.004(0.09) .96 –0.01(0.09) .96
+AD pathology b –0.03(0.10) .79 0.02(0.09) .86 0.02(0.09) .80

The association magnitudes (B) are reported in SD (±SE) change in microglia density per 1 SD increase in tocopherol concentration. Microglia stages I to III represent different stages of microglia activation, microglia density scores were calculated for total count (stage I/II/III), activated microglia (stage II/III), and macrophages (stage III).

SE, standard error.

a

Basic model adjusted for age at death (years), sex, education (years), APOE ε4 (any ε4 vs none) and post‐mortem autopsy time (hours.

b

Basic model +amyloid load and neurofibrillary tangle severity (Braak score).