FIGURE 3.

Chimeric antigen receptor (CAR) T‐cell pharmacokinetics. For second‐generation anti‐CD19 CAR T‐cells for B‐cell malignancies, an initial drop in CAR T‐cell levels after infusion is followed by a period of CAR T‐cell expansion. Peak levels (C_max), typically occur within 14 days (t_max); t_1/2 represents the half‐life, t_last represents the time at which the last measurable level (C_last) was recorded. AUC_0‐28d represents the area under the concentration‐time curve during the first 28 days after CAR T‐cell administration. The y‐axis represents a log‐scale in terms of differences in the CAR T‐cell concentrations