Table 1.

Timeline of pharmacological and laboratory data.

	Day 1	Day 2	Day 3	Day 4	Day 5	Day 7	Day 12	Day 22
Propofol average dose (mg kg−1 h−1)	4.57	7.17	7.49	Stop propofol infusion
Cumulative propofol dose (mg kg−1)	109.6	282	431	–
Norepinephrine dose (μg kg−1 min−1)	0.17	0.19	0.33	0.33	0.24	0.14	0.04	–
C-reactive protein (mg L−1)	240	320	300	301.7	160	57	32	9.4
Procalcitonin (μg L−1)	3.5	3.4	2.5	3.5	2.9	1.5	0.9	0.3
Creatinine (mM)	80	107	139	158	163	218	118	321
Blood urea nitrogen (mM)	6.0	4.6	5.2	5.99	5.6	13.8	6.9	17.2
Aspartate aminotransferase (U L−1)	33	59	22	185	239	188	206	47
Alanine aminotransferase (U L−1)	66	69	68	1838	1253	857	274	57
Creatine phosphokinase (U L−1)	N.A.	N.A.	N.A.	N.A.	33 221	18 069	1907	136
Myoglobin (μg L−1)	N.A.	N.A.	N.A.	N.A.	14 148	7126	2592	299
Phosphate (mM)	0.51	0.58	0.12	1.54	1.37	1.1	1.09	1.95
Lactate (mM)	1.4	1.5	5.1	2.7	1.8	0.9	0.7	0.9
Base deficit (mM)	0.2	1.7	−0.6	−4.6	−1.2	−2.1	−0.6	2.8
High sensitivity troponin I (ng L−1)	36	N.A.	6.2	55	20	6	6	2.5
Plasma triglycerides (mM)	4.38	8.15	16.41	–	–	6.76	5.3	4.1
Albumin (g L−1)	23	22	18	N.A.	20	22	24	29