Table 3.

Clinical Response by Dose Levels

PSA Change From Baselinea	Level 1 (n = 33) N (%)	Level 2 (n = 2) N (%)	Level 3 (n = 4) N (%)	Total (n = 39) N (%)
Maximum decline
≥30%	25 (81)	2 (100)	3(75)	30 (77)
≥50%	24 (77)	1 (50)	3(75)	38 (72)
Decline at 12 wk
≥30%	22 (67)	2 (100)	2(50)	26 (67)
≥50%	21 (64)	1 (25)	1 (25)	23 (59)
RECIST	Level 1 (n = 22) N (%)	Level 2 (n = 2) N (%)	Level 3 (n = 1) N (%)	Total (n = 25) N (%)
Stable disease	4(18)	1 (50)		5(20)
Partial response	18 (82)		1 (100)	19 (76)
Complete response	1 (5)			1 (4)

Abbreviations: PSA = prostate-specific antigen; RECIST = Response Evaluation Criteria In Solid Tumors.

^aBaseline PSA ≥ 2 ng/mL.