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. 2020 Aug 11;9:e61036. doi: 10.7554/eLife.61036

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© 2020, Levitan et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — (A) The BLA of Stk11^f/f mice was infected bilaterally with Cre or control viruses. The ventral GC, where BLA projections terminate (Haley et al., 2016) was implanted with a multi-electrode array 10 days later to record GC taste responses to a battery of four tastes differing in their hedonic value, the palatable sucrose and sodium-chloride and the aversive critic acid and quinine (Levitan et al., 2019). Images show BLA injection site (left) and labeled BLA terminals in the ventral GC co-localized with the site of dye-labeled electrodes (right). (B) PSTHs (colored lines) from a representative GC neuron in a GFP-injected control mouse that responded significantly to all tastes. Dashed line represents the magnitude of the rank correlation between firing rates and behaviorally measured palatability obtained previously in separate experiments (Levitan et al., 2019). (C) Correlation coefficients averaged across all recorded units in GFP (control) and Cre-injected mice. As revealed in a two-way ANOVA, palatability correlations in both groups rise steeply between 800 and 1000 ms with no significant difference between genotypes (F(1,133)=0.13, p=0.72) or interaction (p=0.99). See also Figure 5—figure supplement 1.

Figure 5—figure supplement 1. — (A) The BLA of Stk11^f/f mice was infected bilaterally with Cre or control viruses. The ventral GC, where BLA projections terminate (Haley et al., 2016) was implanted with a multi-electrode array 10 days later to record GC taste responses to a battery of four tastes differing in their hedonic value, the palatable sucrose and sodium-chloride and the aversive critic acid and quinine (Levitan et al., 2019). Images show BLA injection site (left) and labeled BLA terminals in the ventral GC co-localized with the site of dye-labeled electrodes (right). (B) PSTHs (colored lines) from a representative GC neuron in a GFP-injected control mouse that responded significantly to all tastes. Dashed line represents the magnitude of the rank correlation between firing rates and behaviorally measured palatability obtained previously in separate experiments (Levitan et al., 2019). (C) Correlation coefficients averaged across all recorded units in GFP (control) and Cre-injected mice. As revealed in a two-way ANOVA, palatability correlations in both groups rise steeply between 800 and 1000 ms with no significant difference between genotypes (F(1,133)=0.13, p=0.72) or interaction (p=0.99). See also Figure 5—figure supplement 1.