Figure 6. Model of DAZL’s regulation of a broad translation program in undifferentiated spermatogonia.

(A) DAZL promotes robust translation of a broad set of transcripts, ranging from those required for spermatogonial proliferation and differentiation to those that regulate fundamental cellular processes like transcription and RNA splicing. (B) In the absence of DAZL, transcripts normally bound by DAZL are translated less efficiently. (C) DAZL’s broad translational program promotes the expansion of late progenitor (A_al) undifferentiated spermatogonia and subsequent spermatogonial differentiation (‘+DAZL’ arrows). In the absence of DAZL (‘-DAZL’ arrows), both expansion and differentiation occur at reduced rates.