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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Expert Rev Mol Diagn. 2020 Feb 27;20(4):421–441. doi: 10.1080/14737159.2020.1731306

Figure 1.

Figure 1.

Identification of Aβ plaques and vascular amyloidosis in postmortem retinas from Alzheimer’s disease patients. A-D. Representative micrographs of retinal flatmounts of AD patients relative to age- and sex-matched cognitively normal (CN) controls, immunostained against Aβ42 (DAB-12F4). AD patients’ retinas accumulate both abluminal (B, B’) and vascular (D) Aβ42-containing deposits. E. Quantitative immunohistochemical analysis of retinal 12F4+Aβ42 plaques in AD patients vs. CN controls. Adopted from Koronyo et al. JCI Insight 2017 with permission of ASCI via Copyright Clearance Center.