Table 5.
Release kinetics parameters of the microencapsulated IgY during simulated digestion by fitting into different kinetics models
| Encapsulation type | Mathematical model | Digestion condition | Fitted model | R 2 |
| ALG+IgY | Zero-order (Eq. (6)) | SGD | R(t)=13.84t | 0.9973 |
| SID | R(t)=94.31t | 0.8953 | ||
| Higuchi (Eq. (7)) | SGD | R(t)=22.93t 1/2 | 0.9503 | |
| SID | R(t)=168.11t 1/2 | 0.9874 | ||
| Hixson-Crowell (Eq. (8)) | SGD | (311.20−R(t))1/3=6.78−0.11t | 0.9969 | |
| SID | (311.20−R(t))1/3=6.78−1.92t | 0.9944 | ||
| First-order (Eq. (9)) | SGD | R(t)=311.20(1−e − 0.05 t ) | 0.9966 | |
| SID | R(t)=297.70(1−e − 1.15 t ) | 0.9996 | ||
| COS+ALG+IgY | Zero-order (Eq. (6)) | SGD | R(t)=10.35t | 0.9983 |
| SID | R(t)=90.17t | 0.9656 | ||
| Higuchi (Eq. (7)) | SGD | R(t)=17.18t 1/2 | 0.9539 | |
| SID | R(t)=155.30t 1/2 | 0.9942 | ||
| Hixson-Crowell (Eq. (8)) | SGD | (337.49−R(t))1/3 =6.96−0.07t | 0.9982 | |
| SID | (337.49−R(t))1/3 =6.96−1.08t | 0.9969 | ||
| First-order (Eq. (9)) | SGD | R(t)=275.08(1−e − 0.04 t ) | 0.9979 | |
| SID | R(t)=337.49(1−e − 0.57 t ) | 0.9969 |
COS+ALG+IgY and ALG+IgY represent the optimized IgY-loaded ALG microcapsules coated with and without COS, respectively. Microcapsule formulation: ALG concentration, 1.56% (15.6 g/L); COS concentration, 0 or 0.61% (6.1 g/L); IgY/ALG ratio, 62.44% (mass ratio). IgY: immunoglobulin Y; ALG: alginate; COS: chitooligosaccharide; SGD: simulated gastric digestion; SID: simulated intestinal digestion