Table 1.

Details of BAPN-only mouse TAD model

Mouse age and strain	BAPN administration (dose; route; duration)	Occurrence of first death	TAD rate at the BAPN treatment end point	Reference
Three weeks old; C57BL/6	1 g/(kg∙d); in drinking water; four weeks	NG	88.9% TAD; 55.6% TAR	Jia et al., 2015
		NG	77.8% TAD; 33.3% TAR	Jia et al., 2017
		Week 2	70.0% TAR	Xu et al., 2018
		NG	87.5% TAD; 37.5% TAR	Ren et al., 2018
		Week 2	59.3% TAD	Han et al., 2018
		Week 3	81.8% TAD; 42.4% TAR	Wang et al., 2018
		NG	80.0% TAD; 46.7% TAR	Zhou et al., 2019
		Week 2	90.0% TAD; 70.0% TAR	Gao et al., 2019

BAPN: β-aminopropionitrile; NG: not given; TAD: thoracic aortic dissection; TAR: thoracic aortic rupture