Table 2.

Details of sequential BAPN and AngII mouse TAD model

Mouse age	Administration (dose; route; duration)	Mouse strain	Occurrence of first death	TAD rates at the BAPN treatment end point	Effects of AngII on TAD rate	Reference
Three weeks old	BAPN: 1 g/(kg∙d); in drinking water; four weeks +Ang II: 1000 ng/(kg∙min); by pump; 24–72 h	FVB	NG	10% AD	Increase	Kurihara et al., 2012
			NG	25% TAD	Increase	Ren et al., 2016
			Week 2	15% TAR	Increase	Zhao et al., 2019
		C57BL/6	NG	NG	73.2% AD/AR	Anzai et al., 2015
			NG	87% TAD; 20% AR	Remain	Ren et al., 2016
			Week 3	80% AD; 20% AR	Remain	Wang et al., 2016

AD: aortic dissection; AngII: angiotensin II; AR: aortic rupture; BAPN: β-aminopropionitrile; FVB: Friend leukemia virus B; NG: not given; TAD: thoracic aortic dissection; TAR: thoracic aortic rupture