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. 2020 Aug 25;224(3):298.e1–298.e8. doi: 10.1016/j.ajog.2020.08.055

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The placental expression of ACE2 and TMPRSS2 is gestational age dependent

mRNA levels of ACE2 (A) and TMPRSS2 (C) in the first- (7–9 weeks), second- (16–18 weeks), third-trimester spontaneous onset PTB (26–35 weeks) and third-trimester term (38–41 weeks) pregnancies (n=5/group). A and C, ANOVA followed by Tukey’s multiple comparisons test. B and D, Spearman correlation analysis. Data are presented as mean±SD. Different letters if P<.05.

ACE2, angiotensin-converting enzyme 2; ANOVA, analysis of variance; PTB, preterm birth; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SD, standard deviation; SDHA, succinate-ubiquinone oxidoreductase; TMPRSS2, transmembrane protease serine 2; TOP1, topoisomerase 1.

Bloise et al. Angiotensin-converting enzyme 2 and transmembrane protease serine 2 in the maternal-fetal interface across pregnancy. Am J Obstet Gynecol 2021.