Table 2.
Microstructural changes.
| R1 (s−1) | MT (p.u.) | R2* (s−1) | ||||
|---|---|---|---|---|---|---|
| Mean/(95% CI) | p = | (mean/95% CI) | p = p = | (mean/95% CI) | p = | |
| Linear changes over time per month | ||||||
| Thalamus | ||||||
| VAN | ||||||
| Left | − 6.527 (− 11.526 to 1.527) | 0.011 | ||||
| VLN | ||||||
| Left | − 6.054 (− 11.018 to 1.089) | 0.017 | ||||
| Right | − 5.156 (− 9.760 to 0.552) | 0.028 | ||||
| VPN | ||||||
| Left | − 5.185 (− 10.214 to 0.157) | 0.043 | ||||
| Striatum | ||||||
| Ventral striatuml | ||||||
| Left | − 0.020 (− 0.039 to 0.001) | 0.047 | ||||
| Right | − 0.017 (− 0.033 to 0.001) | 0.037 | ||||
| Pre-commissural caudate | ||||||
| Left | − 4.598 (− 8.887 to 0.308) | 0.036 | − 0.020 (− 0.038 to 0.003) | 0.021 | ||
| Post-commissural caudate | ||||||
| Left | − 0.001 (− 0.001 to 0.001) | 0.034 | ||||
| Globus pallidus | ||||||
| Left | − 5.570 (− 10.728 to 0.411) | 0.034 | ||||
| Right | − 5.674 (− 10.763 to 0.585) | 0.029 | ||||
| Acceleration and Deceleration per month2 | ||||||
| Thalamus | ||||||
| VAN | ||||||
| Left | 0.193 (0.032 0.354) | 0.019 | ||||
| VLN | ||||||
| Left | 0.173 (0.0131 0.333) | 0.034 | ||||
| Right | 0.159 (0.011 0.307) | 0.036 | ||||
| Striatum | ||||||
| Pre-commissural caudate | ||||||
| Left | 0.164 (0.025 0.303) | 0.021 | ||||
| Globus pallidus | ||||||
| Left | 0.178 (0.013 0.343) | 0.034 | ||||
| Right | 0.187 (0.024 0.350) | 0.024 | ||||
Rates of changes of myelin-sensitive R1, MT and R2* in patients compared to controls over time. Negative numbers indicate linear decreases, respectively acceleration, in patients compared to controls, whereas positive values indicate linear increases, respectively deceleration.