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. 2020 Aug 24;11(8):703. doi: 10.1038/s41419-020-02838-7

Fig. 6. MLN4924 inhibits ERRβ-mediated breast cancer cell invasion and migration.

Fig. 6

a MDA-MB-231 and b MCF7 cells were treated with 1 µM MLN4924 for 24 h prior to Transwell-migration analysis. Graphical representation determined the average number of migrated cells. (N = 3). The data represent the means ± SD. (One-way ANOVA test; Significant: **P < 0.01, significant). c MDA-MB-231 cells were treated with 1 µM MLN4924 for 24 h prior to invasion analysis. Graphical representation determined the average number of cells. (N = 3). The data represent the means ± SD. (One-way ANOVA test; Significant: *P < 0.05, significant) d MDA-MB-231 cells were untreated, treated with 1 µM MLN4924 and/or ERRβ shRNA prior to invasion analysis. Graphical representation determined the average number of cells. (N = 3). The data represent the means ± SD. (One-way ANOVA test; Significant: *P < 0.05, significant; ns non-significant). Size bar:100 µm. e MDA-MB-231 cells were untreated, treated with 1 µM MLN4924 and/or ERRβ shRNA prior to western blot analysis for N-Cadherin, E-Cadherin, Vimentin, ERRβ and GAPDH expression. Representative blots are shown.