Table 2.
Pathways associated with PD-L1 mRNA expression (2 GEO studies*).
| Description | # Genes in overlap (k) | p | FDR q-value |
|---|---|---|---|
| Genes regulated by NFKB in response to TNF | 35 | 5.14e−41 | 2.57e−39 |
| Genes up-regulated in response to IFNG | 32 | 3.08e−36 | 7.7e−35 |
| Genes up-regulated during transplant rejection | 23 | 6.51e−23 | 1.08e−21 |
| Genes defining inflammatory response | 20 | 7.42e−19 | 9.27e−18 |
| Genes up-regulated in response to alpha interferon proteins | 12 | 6.06e−13 | 6.06e−12 |
| Genes mediating programmed cell death (apoptosis) by activation of caspases | 14 | 9.73e−13 | 8.11e−12 |
| Genes encoding components of the complement system, which is part of the innate immune system | 15 | 1.29e−12 | 9.21e−12 |
| Genes up-regulated by IL6 via STAT3 | 11 | 4.43e−12 | 2.77e−11 |
| Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis | 14 | 1.86e−11 | 8.45e−11 |
| Genes up-regulated in response to low oxygen levels (hypoxia) | 14 | 1.86e−11 | 8.45e−11 |