Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 24;11:4220. doi: 10.1038/s41467-020-18002-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Top panel, scheme illustration of the behavioral procedure: fear conditioning (Day 1), memory tests (Day 2), trauma re-contextualization (ReC) by complete re-exposure to trauma-related cues (vs. partial re-exposure to the tone alone, context alone, or tone and context spaced out of 2 h; Day 3) in control Veh-injected (n = 9), control CORT-injected (n = 8) and CORT-injected mice exposed to dCA1 inhibition during re-exposure (n = 7), memory tests (Day 4 and Day 30). a The normalized contextual fear memory (attested by the absence of fear response to the tone together with high conditioned fear to the context) induced by trauma re-contextualization (PTSD ReC) and the remained PTSD-like memory (i.e. attested by abnormal fear response to the tone and low conditioned fear to the context) subsequent to dCA1 inhibition during re-contextualization persist for at least 30 days after trauma (Tone test: repeated measures × laser condition: F_4,42 = 4.717; P = 0.0031; Context test: laser condition: F_2,21 = 5.489; P = 0.0121; PTSD ReC vs CA1 Inhib: P = 0.253). b–d The remained PTSD-like memory subsequent to partial re-exposure to trauma-related cues persists whatever the re-exposure condition (to the tone alone, context alone, or tone and context spaced out of 2 h; minimum significance in the tone test: repeated measures × Veh/CORT: F_2,34 = 7.935; P = 0.0015; in the context test: Veh/CORT: F_1,17 = 4.607; P = 0.0466, repeated measures × Veh/CORT: F_2,34 = 4.266; P = 0.0022). The blue and gray bars symbolize the conditioning context and the familiar/safe chamber, respectively; Pre-T Pre-Tone, Post-T Post-Tone. Data are presented as mean ± SEM. This experiment was repeated independently once with similar results, See table in the “Animals” section of the “Methods” for detailed sample size. Statistical significance was assessed by repeated measures (three 2 min-blocks) two-sided ANOVA with post hoc test when appropriate. *P < 0.05; **P < 0.01; ***P < 0.005. ^#: block × condition interaction (P < 0.05); ^##P < 0.01; ^###P < 0.005. Source data are provided as a Source Data file.