Table 3.

Multivariate analyses of cancer special survival (CSS) and overall survival (OS) for included patients.

Variables	CSS		OS
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age		< 0.001		< 0.001
< 65	Reference		Reference
≥ 65	1.354 (1.163, 1.576)		1.695 (1.478, 1.943)
Marital status		0.378		0.158
Unmarried	Reference		Reference
Married	0.939 (0.815, 1.080)		0.914 (0.807, 1.036)
Race		0.021		0.022
Black	Reference		Reference
White	0.901 (0.707, 1.148)	0.399	0.859 (0.691, 1.068)	0.171
Other	1.233 (0.902, 1.686)	0.190	1.126 (0.846, 1.500)	0.415
Primary site		0.111		0.032
Cecum–transverse colon	Reference		Reference
Descending colon–sigmoid	1.039 (0.842, 1.283)	0.718	1.065 (0.883, 1.284)	0.513
Multiple	1.414 (0.827, 2.416)	0.205	1.323 (0.790, 2.215)	0.288
Rectum	1.097 (0.825, 1.458)	0.523	1.182 (0.915, 1.525)	0.201
Unknown	2.106 (1.153, 3.845)	0.015	2.143 (1.278, 3.594)	0.004
Grade		0.008		0.008
Grade I/II	Reference		Reference
Grade III/IV	1.570 (1.136, 2.169)	0.006	1.514 (1.149, 1.997)	0.003
Unknown	1.808 (1.244, 2.628)	0.002	1.638 (1.179, 2.274)	0.003
Tumor size		< 0.001		< 0.001
≤ 5 cm	Reference		Reference
> 5 cm	1.211 (1.043, 1.406)		1.138 (0.998, 1.298)	0.054
Unknown	1.691 (1.338, 2.138)		1.524 (1.230, 1.889)	< 0.001
AJCC stage		< 0.001		< 0.001
II	Reference		Reference
III	3.651 (2.967, 4.491)		2.688 (2.280, 3.171)
Lymph node dissection		< 0.001		< 0.001
None or biopsy	Reference		Reference
1–3	0.498 (0.312, 0.796)		0.580 (0.382, 0.881)	0.011
≥ 4	0.413 (0.328, 0.520)		0.449 (0.364, 0.553)	< 0.001
Radiotherapy		< 0.001		0.447
No/unknown	Reference		Reference
Yes	1.168 (0.871, 1.567)		1.110 (0.848, 1.454)
Chemotherapy		< 0.001		< 0.001
No/unknown	Reference		Reference
Yes	0.719 (0.612, 0.844)		0.618 (0.537, 0.713)

CSS: cancer‐specific survival; OS: overall survival; HR: hazard ratio.