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. 2020 Aug 24;5:159. doi: 10.1038/s41392-020-00274-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The immune-regulation role of GSDME enhances CDDP sensitivity to regress NSCLC. a Immunohistochemical (IHC) staining of GSDME in a lung cancer tissue microarray (TMA) that contained 90 specimens, GSDME expression was analyzed in paired NSCLC lung cancer and its surrounding tissue, representative images of IHC staining were shown. b The difference of survival time and death number in NSCLC patients with low- and high-GSDME tumors that accepted chemotherapy with platinum. c Representative scanning electronic micrographs of H1299 cells with negative control or GSDME-overexpression lentivirus and then treated with cisplatin. d Representative scanning electronic micrographs of A549 cells with scrambled shRNA or GSDME shRNA lentivirus and then treated with cisplatin. e The representative image and statistical data in nude mice bearing LLC xenografts contained with negative control or GSDME-overexpressing lentivirus. f The representative image and statistical data in C57 mice bearing LLC xenografts contained with negative control or GSDME-overexpressing lentivirus. g CD3⁺, CD49b⁺, CD11c⁺, and F4/80⁺ cell number were analyzed by flow cytometry in mice with indicated LLC tumors treated with cisplatin. h Heatmap of cytokines in mice blood with indicated LLC tumors. i The statistical data of MIP-1α, MIP-1β, MIP-2, and IP-10 levels in mice blood. j A schematic representation of proposed mechanism for the role of GSDME in NSCLC