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. 2020 Aug 24;10:14128. doi: 10.1038/s41598-020-70726-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In-vitro percentage cumulative drug release profile from calcium sulphate hemihydrate (CSH)/nanohydroxyapatite (nHAP) based nanocement (NC) for 12 weeks. (a) RFP release from NC containing RFP (NC + RFP), (b) RFP release from NC containing RFP and INH (NC + RFP + INH), (c) INH release from NC containing INH (NC + INH), (d) INH release from NC containing RFP and INH (NC + RFP + INH), (e) RFP and INH release pattern from NC containing RFP and INH (NC + RFP + INH). (f) Concentration of RFP released at 4, 8 and 12 week from NC containing RFP (NC + RFP). NC1 = CSH:nHAP (80:20), NC2 = CSH:nHAP (60:40), NC3 = CSH:nHAP (40:60).