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. 2020 Aug 24;11:4225. doi: 10.1038/s41467-020-17880-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Principal Component Analysis of germline variants of GBC and non-GBC samples colored based on country of origin. b Box plot depicting the number of protein-altering mutations in GBC (n = 148), Cholecystitis (n = 9) and GB-other (n = 8) samples containing mutations (1 or more). Boxes indicate the interquartile range (IQR); center line, median; whiskers, lowest and highest values within 1.5x IQR from the first and third quartiles, respectively. c Quilt plot showing mutations in key cancer-associated genes in cholecystitis samples. Each column represents a sample. d Number of protein-altering somatic mutations in GBC compared to mesothelioma⁶⁶ and 21 other cancer types. e MSI score determined by MANTIS plotted against the total number of protein-altering mutations for each GBC sample. Samples are colored based on country of origin as in panel a. MMR gene mutations identified are indicated next to the MSI positive samples.