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. 2020 Aug 24;11:4225. doi: 10.1038/s41467-020-17880-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Plot showing the significantly mutated GBC genes and their q-score. Each gene is represented as a circle, where the size of the circle is proportional to the observed mutation frequency. Genes are arranged along the x axis in alphabetical order. Significant q-score genes with FDR < 0.1 are indicated. Dotted orange line, FDR = 0.05, dotted red line, FDR = 0.1. Schematics showing alterations in ETS family members (b) ELF3 and (c) EHF. d ELF3 splicing defects observed in two GBC samples. e Plot representing mutations observed in SMG genes across the GBC samples. Each column represents a sample. f Kaplan–Meier survival plot of patients with tumor double positive for ELF3 and TP53 vs others. Log-rank test p values are presented for each group. g Schematic showing alterations observed in PSIP1 in GBCs.