Table 2.
Associations of Lead SNPs With RNFL Thickness Parameters From Combined Analyses of All Three Ethnic Groups
| Global RNFL | Superior Quadrant | Inferior Quadrant | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | rs ID | Risk Allele | β* | P Value | β* | P Value | β* | P Value |
| 8q22 | rs284489 | A | 0.454 | 0.045 | 0.693 | 0.056 | 0.799 | 0.036 |
| ABCA1 | rs2472494 | T | −0.127 | 0.574 | −0.070 | 0.847 | −0.523 | 0.169 |
| AFAP1 | rs4619890 | G | −0.194 | 0.401 | −0.533 | 0.141 | −0.232 | 0.556 |
| ANKH | rs76325372 | C | 0.205 | 0.410 | 0.225 | 0.568 | 0.272 | 0.510 |
| ANKRD55 | rs61275591 | A | −0.229 | 0.418 | −0.177 | 0.698 | −0.091 | 0.850 |
| ARHGEF12 | 11:120357425 | AT/A | −0.468 | 0.061 | −0.331 | 0.400 | −0.919 | 0.031 |
| ATOH7 | rs1900004 | T | −0.202 | 0.427 | 0.471 | 0.252 | −0.367 | 0.395 |
| ATXN2 | rs7137828 | C | −0.128 | 0.877 | 0.277 | 0.826 | −0.721 | 0.607 |
| CADM2 | rs34201102 | G | 0.445 | 0.072 | 0.516 | 0.185 | 0.581 | 0.158 |
| CAV1/2 | rs10281637 | C | −0.349 | 0.446 | −0.199 | 0.772 | −0.521 | 0.481 |
| CDKN1A | 6:36592986 | TCA/T | −0.540 | 0.039 | −0.472 | 0.254 | −0.922 | 0.042 |
| CDKN2B-AS1 | rs1360589 | T | −0.749 | 0.019 | −0.979 | 0.052 | −1.269 | 0.015 |
| DGKG | rs9853115 | T | 0.132 | 0.573 | 0.308 | 0.409 | 0.327 | 0.400 |
| EXOC2 | rs2073006 | T | −0.627 | 0.057 | −0.651 | 0.213 | −1.178 | 0.033 |
| FLNB | rs12494328 | A | 0.018 | 0.935 | −0.092 | 0.798 | −0.298 | 0.425 |
| FMNL2 | rs56117902 | C | 0.241 | 0.457 | 0.087 | 0.861 | 0.276 | 0.602 |
| FNDC3B | rs7636836 | T | −0.557 | 0.350 | −1.680 | 0.110 | −0.813 | 0.460 |
| FOXC1 | rs2745572 | A | −0.090 | 0.720 | −0.163 | 0.680 | −0.224 | 0.597 |
| GAS7 | rs9913991 | A | −0.365 | 0.409 | −0.408 | 0.583 | −1.135 | 0.129 |
| GMDS | rs11969985 | G | −0.128 | 0.679 | −0.076 | 0.880 | −0.190 | 0.713 |
| HMGA2 | rs343093 | G | −0.128 | 0.597 | −0.165 | 0.665 | −0.392 | 0.333 |
| IKZF2 | rs56335522 | C | 0.301 | 0.756 | 1.021 | 0.492 | 1.455 | 0.355 |
| LHPP | rs12262706 | G | −0.314 | 0.214 | −0.680 | 0.094 | −0.590 | 0.167 |
| LMO7 | rs9530458 | T | −0.181 | 0.570 | −0.204 | 0.675 | −0.212 | 0.685 |
| LMX1B | rs10819187 | G | 0.207 | 0.447 | 0.142 | 0.738 | 0.173 | 0.707 |
| LOXL1 | rs1048661 | T | 0.158 | 0.489 | 0.077 | 0.834 | 0.152 | 0.693 |
| MEIS2 | rs28480457 | C | 0.402 | 0.424 | −0.103 | 0.899 | −0.065 | 0.940 |
| PDE7B | rs9494457 | A | 0.155 | 0.505 | 0.366 | 0.313 | 0.176 | 0.644 |
| PMM2 | rs3785176 | G | 0.475 | 0.094 | 0.891 | 0.043 | 0.679 | 0.155 |
| SIX6 | rs33912345 | C | −1.116 | 1.64E-5 | −1.646 | 6.54E-5 | −2.015 | 2.9E-6 |
| TAP2 | rs241430 | C | 0.153 | 0.478 | 0.056 | 0.873 | 0.421 | 0.246 |
| TGFBR3-CDC7 | rs1192415 | G | −0.048 | 0.865 | −0.033 | 0.939 | 0.099 | 0.830 |
| TMCO1 | rs4656461 | G | −1.362 | 0.026 | −1.873 | 0.052 | −1.122 | 0.285 |
| TMTC2 | rs324794 | G | −0.117 | 0.686 | −0.103 | 0.821 | −0.301 | 0.531 |
| TXNRD2 | rs35934224 | T | 0.650 | 0.107 | 0.869 | 0.148 | 1.065 | 0.108 |
In bold, Bonferroni-corrected significance value P < 0.0014 (0.05/35).
*
β, Changes in RNFL thickness (in micrometers) per risk allele count. Model adjusted for age, gender, top three genotype PCs.