FIGURE 6.

Morroniside has positive effects on apoptosis, inflammation and ROS generation promoted by high glucose in BMSCs, and these effects are partially reduced by BBGCP2. A, BMSC apoptosis was evaluated by Annexin V/PI assays on day 3 after treatment. B, Cell viability was evaluated by CCK‐8 assays. C, ROS generation in BMSCs was assessed by ROS assay kits. D, Inflammatory cytokines in BMSCs were assessed by ELISA. The data were confirmed by three repeated tests and are presented as the means ± SD. Mor, morroniside. HG, high glucose. FPS‐ZM1, an inhibitor of RAGE signalling. BBGC, BBGCP₂. *P < .05 compared with the high glucose treatment group; **P < .01; ***P < .001. #P < .05 compared with the morroniside treatment group; ##P < .01; ###P < .001