TABLE 3.

The anti‐tumour effects of propofol in combination with chemotherapy drugs or molecular compounds in cancer cells

Chemotherapy drugs or molecular compounds	Cancer types	Downstream gene regulated by propofol	Functions	Ref.
Cisplatin	Cervical cancer	EGFR/JAK2/STAT3 pathway	Enhances the chemosensitivity	75
Cisplatin	Ovarian cancer	Activates FOXO1	Promotes cell apoptosis	76
Paclitaxel	Ovarian cancer	Downregulates Slug	Promotes cell apoptosis	77
Gemcitabine	Pancreatic cancer	Downregulates NF‐κB signalling pathway	Enhances the chemosensitivity	78
Docetaxel	Prostate cancer	Downregulates HIF‐1α	Enhances the chemosensitivity	80
LPS	Non‐small cell lung cancer	Downregulates HIF‐1α	Inhibits EMT, migration and invasion	81

Abbreviations: EGFR, epidermal growth factor receptor; EMT, epithelial‐mesenchymal transition; FOXO1, Forkhead Box O1; HIF‐1α, hypoxia‐inducible factor‐1α; JAK2, Janus kinase 2; LPS, lipopolysaccharide; NF‐κB, nuclear factor‐kappa B; STAT3, signal transducer and activator of transcription 3.