Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 20;396(10249):467–478. doi: 10.1016/S0140-6736(20)31604-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Live SARS-CoV-2 neutralisation assays (Marburg VN and PHE PRNT₅₀) and microneutralisation assays (PHE MNA)

Panels A and B show live SARS-CoV-2 neutralisation (Marburg VN) in prime (A) and prime boost (B) trial participants (boosted at day 28) and convalescent plasma from patients with PCR-confirmed COVID-19 and asymptomatic health-care workers. Panels C, E, and F show the PHE MNA (at IC₅₀, IC₈₀, and IC₉₀, respectively) and panel D the PHE PRNT₅₀. The day 42 timepoint was only measured in participants who received a booster dose at day 28. Solid lines connect samples from the same participant. Boxes show median (IQR). Dotted lines show upper limits of detection. MenACWY=meningococcal group A, C, W-135, and Y conjugate vaccine. PHE=Public Health England. MNA=microneutralisation assay. PRNT=plaque reduction neutralisation test. VN=virus neutralisation. IC=inhibitory concentration. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2. *ELISA results for these five convalescent plasma samples are shown in figure 3 as red stars.