Table 3.
Mutant Profiles of MDR-TB Isolates Within pncA
| Nucleotide Position | Nucleotide Change | Amino Acid Position | Amino Acid Change | No. of Isolates | |
|---|---|---|---|---|---|
| Substitution | |||||
| 1 | −12 | T to C | Promoter | – | 5 |
| 2 | −11 | A to G | Promoter | – | 1 |
| 3 | 3 | ATG to ATA | 1 | Met to Ile | 1 |
| 4 | 11 | TTG to TCG | 4 | Leu to Ser | 1 |
| 5 | 14 | ATC to AGC | 5 | Ile to Ser | 1 |
| 6 | 19 | GTC to TTC | 7 | Val to Phe | 2 |
| 7 | 20 | GTC to GGC | 7 | Val to Gly | 1 |
| 8 | 24 | GAC to GAA | 8 | Asp to Glu | 1 |
| 9 | 24 | GAC to GAG | 8 | Asp to Glu | 1 |
| 10 | 26 | GTG to GCG | 9 | Valto Ala | 2 |
| 11 | 26 | GTG to GGG | 9 | Val to Gly | 1 |
| 12 | 28 | CAG to TAG | 10 | Gln to Stop | 1 |
| 13 | 29 | CAG to CCG | 10 | Gln to Pro | 1 |
| 14 | 35 | GAC to GCC | 12 | Asp to Ala | 2 |
| 15 | 35 | GAC to GGC | 12 | Asp to Gly | 1 |
| 16 | 37* | TTC to GTC | 13 | Phe to Val | 1 |
| 17 | 40* | TGC to GGC | 14 | Cys to Gly | 1 |
| 18 | 40 | TGC to CGC | 14 | Cys to Arg | 1 |
| 19 | 41 | TGC to TAC | 14 | Cys to Tyr | 1 |
| 20 | 50 | GGC to GAC | 17 | Gly to Asp | 1 |
| 21 | 56 | CTG to CCG | 19 | Leu to Pro | 1 |
| 22 | 62 | GTA to GGA | 21 | Val to Gly | 3 |
| 23 | 71 | GGC to GAC | 24 | Gly to Asp | 1 |
| 24 | 77 | GCG to GGG | 26 | Ala to Gly | 1 |
| 25 | 83 | GCC to GAC | 28 | Ala to Asp | 1 |
| 26 | 94 | TTC to GTC | 32 | Phe to Val | 1 |
| 27 | 104 | CTG to CCG | 35 | Leu to Pro | 1 |
| 28 | 105* | CTG to CTC | 35 | Leu to Pro | 1 |
| 29 | 123 | TAC to TAG | 41 | Tyr to Stop | 1 |
| 30 | 128 | CAC to CCC | 43 | His to Pro | 1 |
| 31 | 136 | GCA to CCA | 46 | Ala to Pro | 1 |
| 32 | 145 | GAC to AAC | 49 | Asp to Asn | 1 |
| 33 | 146 | GAC to GGC | 49 | Asp to Gly | 1 |
| 34 | 146 | GAC to GCC | 49 | Asp to Ala | 1 |
| 35 | 152 | CAC to CGC | 51 | His to Arg | 1 |
| 36 | 160 | CCG to TCG | 54 | Pro to Ser | 1 |
| 37 | 161* | CCG to CGG | 54 | Pro to Arg | 1 |
| 38 | 161 | CCG to CAG | 54 | Pro to Glu | 1 |
| 39 | 170* | CAC to CGC | 57 | His to Arg | 1 |
| 40 | 171 | CAC to CAA | 57 | His to Gln | 1 |
| 41 | 172 | TTC to GTC | 58 | Phe to Val | 1 |
| 42 | 185 | CCG to CGG | 62 | Pro to Arg | 1 |
| 43 | 194* | TCC to TGC | 65 | Ser to Cys | 1 |
| 44 | 196 | TCG to CCG | 66 | Ser to Pro | 1 |
| 45 | 202 | TGG to CGG | 68 | Trp to Arg | 1 |
| 46 | 203 | TGG to TCG | 68 | Trp to Ser | 1 |
| 47 | 203 | TGG to TAG | 68 | Trp to Stop | 2 |
| 48 | 212 | CAT to CGT | 71 | His to Arg | 1 |
| 49 | 212* | CAT to CCT | 71 | His to Pro | 1 |
| 50 | 226 | ACT to CCT | 76 | Thr to Pro | 4 |
| 51 | 254 | CTG to CGG | 85 | Leu to Arg | 1 |
| 52 | 269* | ATC to ACC | 90 | Ile to Thr | 1 |
| 53 | 287 | AAG to AGG | 96 | Lys to Arg | 1 |
| 54 | 290 | GGT to GAT | 97 | Gly to Asp | 1 |
| 55 | 305 | GCG to GTG | 102 | Ala to Val | 1 |
| 56 | 308 | TAC to TGC | 103 | Tyr to Cys | 1 |
| 57 | 314 | GGC to GAC | 105 | Gly to Asp | 1 |
| 58 | 317* | TTC to TCC | 106 | Phe to Ser | 1 |
| 59 | 359 | CTG to CGG | 120 | Leu to Arg | 7 |
| 60 | 374 | GTC to GGC | 125 | Val to Gly | 1 |
| 61 | 374* | GTC to GCC | 125 | Val to Ala | 1 |
| 62 | 398 | ATT to ACT | 133 | Ile to Thr | 2 |
| 63 | 407 | GAT to GGT | 136 | Asp to Gly | 1 |
| 64 | 412 | TGT to CGT | 138 | Cys to Arg | 1 |
| 65 | 416 | GTG to GGG | 139 | Val to Gly | 2 |
| 66 | 424 | ACG to CCG | 142 | Thr to Pro | 1 |
| 67 | 425 | ACG to ATG | 142 | Thr to Met | 1 |
| 68 | 437 | GCG to GTG | 146 | Ala to Val | 1 |
| 69 | 463 | GTG to ATG | 155 | Val to Met | 1 |
| 70 | 466* | CTG to TTG | 154 | Leu to Leu | 1 |
| 71 | 467* | CTG to CAG | 156 | Leu to Gln | 1 |
| 72 | 467 | CTG to CCG | 156 | Leu to Pro | 1 |
| 73 | 478 | ACA to CCA | 160 | Thr to Pro | 1 |
| 74 | 511 | GCG to ACG | 171 | Ala to Thr | 1 |
| 75 | 511 | GCG toCCG | 171 | Ala to Arg | 1 |
| 76 | 519* | GAG to GAA | 173 | Glu to Glu | 1 |
| 77 | 535* | AGC to TGC | 179 | Ser to Cys | 2 |
| 78 | 541* | GAG to TAG | 181 | Glu to Arg | 1 |
| 79 | 543 | GAG to GAT | 181 | Glu to Arg | 1 |
| 80 | 555* | AGC to AGT | 185 | Ser to Ser | 1 |
| deletion | |||||
| 81 | 79 to 92* | CTGGCCCGCGCCAT deletion | 27 | Frameshift | 1 |
| 82 | 189 to 218* | CTATTCCTCGTCGTGGCCACCGCATTGCGT deletion | 63 | Frameshift | 1 |
| 83 | 196 to 221* | TCGTCGTGGCCACCGCATTGCGTCAG deletion | 64 | Frameshift | 1 |
| 84 | 200* | C deletion | 84 | Frameshift | 1 |
| 85 | 246* | T deletion | 141 | Frameshift | 1 |
| 86 | 329 | A deletion | 110 | Frameshift | 1 |
| insertion | |||||
| 87 | −7* | G insertion | promoter | – | 1 |
| 88 | 121* | ACG insertion | 41 | Asp insertion | 1 |
| 89 | 130* | AG insertion | 44 | Frameshift | 1 |
| 90 | 201* | GT insertion | 67 | Frameshift | 1 |
| 91 | 240* | CGGA insertion | 81 | Frameshift | 1 |
| 92 | 253* | C insertion | 85 | Frameshift | 1 |
| 93 | 256* | G insertion | 86 | Frameshift | 1 |
| 94 | 268* | T insertion | 90 | Frameshift | 2 |
| 95 | 391 | G insertion | 131 | Frameshift | 1 |
| 96 | 392 | GG insertion | 131 | Frameshift | 1 |
| 97 | 411* | TG insertion | 137 | Frameshift | 1 |
| 98 | 417* | AG insertion | 140 | Frameshift | 1 |
| 99 | 447* | T insertion | 150 | Frameshift | 1 |
| 100 | 534* | G insertion | 179 | Frameshift | 1 |
| Multiple mutations | |||||
| 1 | 11,478, 535,541 | TTG to TCG, ACA to CCA, AGC to TGC, GAG to TAG | 4,160,179,181 | Leu to Ser, Thr to Pro, Ser to Cys, Glu to Arg | 1 |
| 2 | 24,35, 254, 412 | GAC to GAA, GAC to GCC, CTG to CGG, TGT to CGT | 8,12,85,138 | Asp to Glu, Asp to Gly, Leu to Arg, Cys to Arg | 1 |
| 3 | 105,121, 203 |
CTG to CTC, ACG insertion, TGG to TCG | 35,44 | Leu to Pro, Aspinsertion,Trp to Ser | 1 |
| 4 | 26,40,398 | GTG to GCG, TGC to GGC, ATT to ACT | 9,14,133 | Val to Ala, Cys to Gly, Ile to Thr | 1 |
| 5 | 56,145,463 | CTG to CCG, GAC to AAC, GTG to ATG | 19,49,155 | Leu to Pro, Asp to Asn, Val to Met | 1 |
| 6 | 19,437 | GTC to TTC, GCG to GTG | 71,46 | Val to Phe, Ala to Val | 1 |
| 7 | 77,171 | GCG to GGG, CAC to CAA | 26,57 | Ala to Gly, His to Gln | 1 |
| 8 | 40,104 | TGC to CGC, CTG to CCG | 14,35 | Cys to Arg, Cys to Arg | 1 |
| 9 | 37,128, | TTC to GTC, CAC to CCC | 13,43 | Phe to Val, His to Pro | 1 |
| 10 | 160,253 | CCG to CTG, C insertion | 54,85 | Pro to Ser, Frameshift | 1 |
| 11 | 196,212 | TCG to CCG, CAT to CCT | 66,71 | Ser to Pro, His to Pro | 1 |
| 12 | 29,287 | CAG to CCG, AAG to AGG | 10,96 | Gln to Pro, Lys to Arg | 1 |
| 13 | 161,200 | CCG to CGG, C deletion | 54,84 | Pro to Arg, Frameshift | 1 |
Note: *Not found in the TBDRM and GMTV databases or in previous studies.