Table 6.
Efficacy Evaluation of Sequencing for PZA Resistance in MDR Strains
| gene | PZA Resistant (n=105) | PZA Susceptible (n=47) | Sensitivity (%) (95% CI) |
Specificity (%) (95% CI) |
Kappa Coefficient | ||
|---|---|---|---|---|---|---|---|
| Substitutions Mutation and Indel | No Mutation and Synonymous Mutation | Substitutions Mutation and Indel | No Mutation and Synonymous Mutation | ||||
| pncA | 94 | 11 | 5 | 42 | 89.52 (81.64–94.39) | 89.36 (76.10–96.01) | 0.76 |
| rpsA | 7 | 98 | 0 | 47 | 6.67 (2.94–13.68) | 100 (92.45–100.00) | 0.07 |
| panD | 2 | 103 | 0 | 47 | 1.90 (0.23–6.70) | 100 (92.45–100.00) | 0.01 |
| pncA/rpsA/panD | 97 | 8 | 5 | 42 | 92.38 (85.54–96.65) | 89.36 (76.10–96.01) | 0.8 |