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. 2020 Aug 20;15:6247–6262. doi: 10.2147/IJN.S262876

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© 2020 Li et al.

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Combined application of ZnO-NPs and silver exerts a synergistic osteogenesis effect.

Notes: (A) Schematic of Ag/ZnO dual-decorated micro-/nanoporous SPEEK preparation process, and its bactericidal effect and osteogenic activity. (B) Scanning electron microscopy images of SPEEK, Ag-SPEEK, Zn-SPEEK, and Ag/Zn-SPEEK. (C) Biological activities of different samples: (c1) proliferation of MG-63 on various sample surfaces for 1, 3, and 5 days; (c2) ALP activity of MG-63 cells on various samples for 7 days. Data are presented as mean ± standard deviation: *P < 0.05, ^#P < 0.05 compared with other groups, and ^##P < 0.01 compared with other groups. Reprinted from Deng Y, Yang L, Huang Xet al Dual Ag/ZnO-Decorated Micro-/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer-by-Layer Self-Assembly Strategy. Macromol Biosci. 2018;18(7): e1800028, with permission from Copyright (2018) John Wiley and Sons.

Abbreviations: ALP, alkaline phosphatase; SPEEK, sulfonated polyetheretherketone; ZnO-NPs, zinc oxide nanoparticles.