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. 2020 Aug 18;9:131–140. doi: 10.2147/ITT.S263690

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© 2020 Peyravian et al.

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Transient receptor potential vanilloid 1 (TRPV1) signaling. TRPV1 activation initiates down-stream signaling of three major pathways including PI3K/AKT. Transforming growth factor-activated kinase 1 (TAK-1) dependent c-jun terminal kinase (JNK)/MAPK and Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascades may also be activated as a result of TRPV1 activation leading to nuclear factor-κB (NF-κB) activation within the nucleus and transcription of target genes.