Table 1.

Delta Trial inclusion criteria and consent process.

Participants are eligible to perform	Inclusion criteria or actions required
Adaptive digital questionnaire (selection through eligibility screening, consent, and enrollment)	Age 18-45 years UK resident Not pregnant or breastfeeding Not suicidal Patient Health Questionnaire 9 score ≥5 Consent to having read participant information sheet Consent to voluntary participation Select link in the confirmation email
DBSa and CIDIb (selection through consent, digital questionnaire responses, and internal analysis; only eligible once the digital questionnaire is completed)	Consent to provide DBS samples and complete CIDI No blood-borne illness No previous diagnosis of schizophrenia Recruiting target not yet reached for baseline mood disorder diagnosis group (major depressive disorder, bipolar disorder, or low moodc)

^aDBS: dried blood spot.

^bCIDI: Composite International Diagnostic Interview.

^cLow mood: no mood disorder diagnosis.