Table 3.
Clinical characteristics at baseline of patients with breast cancer and prostate cancer.
| Characteristics | Breast cancer (n=74) | Prostate cancer (n=75) | Test statistic | P value | |
| Charlson Comorbidity Scale scorea, median (IQR) | 1.0 (1) | 3.0 (1) | 5082.5b | <.001b | |
| PSAc (at start of treatment), median (range) | N/Ad | 5.3 (0-53) |
|
|
|
| Disease stage (TNMe), n (%) |
|
|
|
|
|
|
|
T1 | N/A | 1 (1) |
|
|
|
|
T1C | N/A | 17 (23) |
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|
|
|
T2 | N/A | 11 (15) |
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|
|
|
T2A | N/A | 1 (1) |
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|
|
|
T2B | N/A | 7 (9) |
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|
|
|
T2C | N/A | 7 (9) |
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|
|
|
T3 | N/A | 20 (27) |
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|
|
|
T3A | N/A | 1 (1) |
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|
|
|
T3B | N/A | 8 (11) |
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|
|
|
Missing | N/A | 2 (3) |
|
|
| Histologic grade (Elston-Ellis), n (%) |
|
|
|
|
|
|
|
Intermediate grade 2 | 23 (31.1) | N/A |
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|
|
|
High grade 3 | 41 (55.4) | N/A |
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|
|
|
Unknown | 10 (13.5) | N/A |
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|
| Tumor characteristicsf, n (%) |
|
|
|
|
|
|
|
HER2+ ER+ PR+ | 9 (12.2) | N/A |
|
|
|
|
HER2+ ER+ PR– | 7 (9.5) | N/A |
|
|
|
|
HER2+ ER– PR– | 13 (17.6) | N/A |
|
|
|
|
HER2– ER+ PR+ | 16 (21.6) | N/A |
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|
|
|
HER2– ER+ PR– | 7 (9.5) | N/A |
|
|
|
|
HER2– ER– PR+ | 1 (1.4) | N/A |
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|
|
|
Triple negative | 21 (28.4) | N/A |
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|
| Proliferation rate (Ki-67), n (%) |
|
|
|
|
|
|
|
≥ 20 % | 72 (97.3) | N/A |
|
|
|
|
< 20 % | 2 (2.7) | N/A |
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|
| Type of chemotherapy, n (%) |
|
|
|
|
|
|
|
Anthracyclines, alkylators | 3 (4.1) | N/A |
|
|
|
|
Anthracyclines, alkylators, taxanes | 37 (50.0) | N/A |
|
|
|
|
Anthracyclines, alkylators, antimetabolites, taxanes | 9 (12.2) | N/A |
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|
|
|
Antimetabolites, alkylators | 2 (2.7) | N/A |
|
|
|
|
Taxanes | 11 (14.9) | N/A |
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|
|
|
Taxanes, alkylators | 1 (1.4) | N/A |
|
|
|
|
Taxanes, trastuzumab emtansine | 2 (2.7) | N/A |
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|
|
|
Trastuzumab emtansine | 9 (12.2) | N/A |
|
|
| Gleason score, median (range) | N/A | 7 (6-9) |
|
|
|
| Number of radiotherapy treatments, median (range) | N/A | 25 (25-29) |
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|
|
| Number of neoadjuvant chemotherapy treatments, median (range) | 6.0 (2-15) | N/A |
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|
|
| Antihormonal treatment, n (%) |
|
|
|
|
|
|
|
Yes | N/A | 55 (73) |
|
|
|
|
No | N/A | 20 (27) |
|
|
| Treatment duration (in weeks), median (range) | 15 (3-26) | 5 (5-6) |
|
|
|
aA higher value corresponds to greater comorbidity; the score ranges between 0-37.
bMann-Whitney U test.
cPSA: Prostate-specific antigen.
dN/A: not applicable.
eTNM: Classification of malignant tumors.
fBreast cancer cell human epidermal growth factor receptor (HER2), estrogen receptor (ER), and progesterone receptor (PR) status.