Table. Clinical Features of Patients With Parkinson Disease and Notch Homolog 2 N-Terminal-Like C (NOTCH2NLC) Repeat Expansions Greater Than 40^a.

Patient No.	Tremor-dominant PD	Age, decade	Age at onset, decade	Imaging results	Dementia	Peripheral neuropathy	NOTCH2NLC repeat size	No. (%)
								GGC	GGA	AGC	Others
1	Yes	60s	50s	MRI: normal	No	No	122	102 (79.7)	0	20 (15.6)	6 (4.7)
2	Yes	80s	70s	MRI: periventricular ischemia, mild atrophy	No	No	79	66 (83.5)	0	13 (16.5)	0
3	No	80s	60s	CT: mild cerebral atrophy	Developed cognitive impairment in late 80s	No	130	75 (57.7)	0	55 (42.3)	0
4	Yes	80s	70s	MRI: subperiventricular ischemia	No	No	64	61 (95.3)	2 (1.6)	1 (3.1)	0
5	Yes	80s	70s	No neuroimaging done	No	No	62	62 (100)	0	0	0
6	Yes	60s	50s	No neuroimaging done	No	No	60	59 (98.3)	1 (1.7)	0	0
7	No	60s	50s	MRI: normal	No	No	49	47 (95.9)	2 (4.1)	0	0
8	Yes	80s	30s	CT: lacunar infarct in external capsule	No	No	47	NA	NA	NA	NA
9	No	70s	60s	CT: subcortical and periventricular ischemia	No	Yes (associated with diabetes)	41	40 (97.5)	1 (2.5)	0	0
10	No	70s	60s	MRI: periventricular ischemia	No	No	47	45 (95.7)	2 (4.3)	0	0
11	No	60s	60s	No neuroimaging done	No	No	42	NA	NA	NA	NA
12	No	70s	60s	CT: normal	No	No	41	39 (92.9)	2 (2.4)	1 (4.8)	0
13	Yes	70s	70s	CT: chronic microvascular ischemia	No	No	41	NA	NA	NA	NA

Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; NA, not available; PD, Parkinson disease.

^aAll patients were ethnically Chinese and had no family history of Parkinson disease. They did not show any sign of ataxia or other complications, such as motor fluctuations or dyskinesias.