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Effects of HDACi and its associated signaling pathways in renal interstitial fibrosis. HDACi is showing to protect against interstitial fibrosis through multiple signaling pathway as indicated. EGF, epidermal growth factor; TGF, transforming growth factor; TGFR, TGF-receptor; HDACi, histone deacetylases inhibitor; STAT3, signal transducer and activator of transcription 3; α-SMA, α-smooth muscle actin.
