Table 1.

Classification of HDACs and its expression in kidney

Group	Member	Cellular distribution	Renal location	Aberration	Reference
Class I	HDAC1	Nucleus	Renal fibroblasts and tubular cell	Up	[36, 37, 38, 39]
	HDAC2			Up	[36, 37, 38, 39]
	HDAC3			Down/up	[37, 40]
	HDAC8			Down/up	[38, 43]
Class II	HDAC4	Nucleus/cytoplasm	Renal tubules	Up	[39]
	HDAC5			Up	[38]
	HDAC6			Up	[38, 41]
	HDAC7			Up	[36]
	HDAC9			ND
	HDAC10			Up	[38]
Class III	Sirt1	Cytoplasm/nucleus/mitochondria	Renal tubules and fibroblasts	Down	[23]
	Sirt2			Up	[25]
	Sirt3			Down	[27]
	Sirt4			ND
	Sirt5			ND
	Sirt6			ND
	Sirt7			ND
Class IV	HDAC11	Mainly nucleus	Renal tubule	ND

HDACs, histone deacetylases.