Skip to main content
. 2020 Jul 23;85(16):10797–10805. doi: 10.1021/acs.joc.0c01311

Table 1. Summary of High-Throughput Ligand Screening for the Vinylation of 23 with Ethylene Gas.

graphic file with name jo0c01311_0010.jpg

    HPLC (area %)
entry cat (mol %) 23 19
1 PdCl2 (20), (p-Tol)3P (40) 20.2 53.6
2 PdCl2 (20), (o-MeOC6H4)3P (40) 43.6 9.2
3 Pd(OAc)2 (20), Xantphos (20)a 12.3 70.7
4 Pd(dppf)Cl2·CH2Cl2 (10) 69.6 13.8
5 PdCl2 (20), DPEphos (20) 0.9 61.1
6 Scheme 4, method B NDb 94.5
a

The reaction was conducted in DMF (50 v/w) in the absence of PTZ.

b

ND = not detected.