Skip to main content
. 2020 Jul 23;85(16):10797–10805. doi: 10.1021/acs.joc.0c01311

Table 2. Summary of High-Throughput Catalyst Screening for the Asymmetric Reduction of 17.

graphic file with name jo0c01311_0011.jpg

entry reductant cat conditions HPLC area % % ee
1 H2 (3 MPa) 27 tBuOK (10 equiv), MeOH, 40 °C 25.9 100
2 H2 (3 MPa) 28 nBu4NI (10 equiv), AcOH/toluene 40 °C 93.5 34.2
3 H2 (3 MPa) 29 MeOH/THF, 40 °C 82.3 85.5
4 HCOOH (6 equiv) 30 Et3N (2.4 equiv), DMF, rt 89.1 82.7