Table 1.
Epithelial layer thickness and inflammation in the common bile duct after stent placement
| Thickness of the epithelial layer (μm) |
Degree of inflammatory cell infiltration |
||||
| - | + | ++ | +++ | ||
| Control (n = 3) | 103 ± 24.1 | 1 | 2 | 0 | 0 |
| PLCL-0 stent (n = 6) | 209 ± 45.4a | 0 | 5 | 1 | 0 |
| PLCL-GEM stent (n=6) | 259 ± 77.3a | 0 | 4 | 2 | 0 |
| PLCL-CIS stent (n=6) | 255 ± 64.2a | 0 | 3 | 3 | 0 |
| PLCL-GC stent (n=6) | 287 ± 81.8a | 0 | 3 | 3 | 0 |
| P value | 0.157 | ||||
None (-), mild (+), moderate (++), and severe (+++).
a
P < 0.05 vs control. CBD: Common bile duct; CIS: Cisplatin; GEM: Gemcitabine; PLCL: Poly- L-lactide-caprolactone; PLCL-0: Non-drug-loaded PLCL nanofilm; PLCL-CIS: PLCL nanofilm loaded with CIS; PLCL-GEM: PLCL nanofilm loaded with GEM; PLCL-GC: PLCL nanofilm loaded with both GEM and CIS.