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. 2020 May 18;27(7):329–337. doi: 10.1038/s41434-020-0155-7

Fig. 3. Different strategies are used in constructing the synthetic promoter.

Fig. 3

ProA: A 5′ end of a specific type of inner ear cell-specific expressed gene −3000 to 500 bp. ATG is the translation start site. ProB: A phylogenetic conserved sequence before the transcription initiation site of a gene specifically expressed by at least two specific types of inner ear cells. ProC: Transcription factor binding site (TFBS) repeats for multiple specific types of inner ear cell-specific transcription factors. ProD: Hypomethylated sequences of cis-acting elements of genes specifically expressed by specific types of inner ear cells.