Table 1.

Clinical and pathology features of each RMS subtype

Feature	Embryonal	Alveolar	Spindle cell/sclerosing	Pleomorphic
Frequent localisation	Mucosae, Urogenital, Head, Neck	Head and neck, Extremities	Head and neck	Ubiquitous
Prevalence	10–20%	20–30%	5–10%	50–60%
Prognosis	Poor	Poor	Variable	Poor
Histo-morphology	Round and spindled proliferation within a myxoidstroma	Round cells with fibrous septa	Homogeneous proliferation of spindle-like cells (spindled and sclerosing/epithelioid)	Heterogeneous cells in shape and size (pleomorphism)
Immunohistochemistry	Heterogeneous MYOD1/myogenin	Diffuse MYOD1/Myogenin	MYOD1 >myogenin	Scant MYOD1/myogenin
Genetic features	Drivers unknown	FOX01 fusion	VGLL2/NCOA2 fusions, TFCP2 fusions, MYOD1 activatingmutations	Complexgenetics

RMS, rhabdomyosarcomas.