Table 3.
Diagnostic performance of fecal biomarkers and SUVmean in predicting endoscopically active disease
| Sensitivity (95% CI) | Specificity (95% CI) | Accuracy (95% CI) | Optimal Cutoff | AUC of ROC | p values* | |
|---|---|---|---|---|---|---|
| SUVmean | 0.684 (0.536–0.832) | 0.909 (0.739–1) | 0.735 (0.727 0.742) | 1.16 (µg/g) | 0.792 | 0.012 |
| Calprotectin | 0.632 (0.478–0.785) | 0.818 (0.59–1) | 0.673 (0.665–0.682) | 139.02 (µg/g) | 0.739 | 0.021 |
| Lactoferrin | 0.895 (0.797–0.992) | 0.909 (0.739–1) | 0.898 (0.894–0.902) | 9.90 (µg/g) | 0.9 | <0.001 |
| PMN-e | 0.684 (0.536–0.832) | 0.818 (0.59–1) | 0.714 (0.706–0.722) | 0.105 (ng/ml) | 0.768 | 0.021 |
| EDN | 0.684 (0.536–0.832) | 0.909 (0.739–1) | 0.734 (0.727–0.742) | 1.68 (µg/g) | 0.815 | 0.01 |
| S100A12 | 0.763 (0.628–0.898) | 0.818 (0.59–1) | 0.776 (0.769–0.782) | 58.12 (µg/g) | 0.761 | 0.021 |
AUC, area under the curve; CI, Confidence interval; EDN, eosinophil-derived neurotoxin; PMN-e, polymorphonuclear leukocyte elastase ; ROC, receiver operating characteristics; SUVmean, mean value of maximum of standardized uptake value ratio gut/liver.
a
p values was determined by receiver operating characteristics