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. Author manuscript; available in PMC: 2021 Aug 7.
Published in final edited form as: Org Lett. 2020 Jul 29;22(15):5753–5757. doi: 10.1021/acs.orglett.0c02238

Scheme 2. Cu/NFSI Fluorination of Benzylic C–H Bonds.

Scheme 2.

a1H or 19F NMR yields; CH2Br2 or PhCF3 as internal standard. b35 °C, 0.5 equiv MeB(OH)2. c55 °C, 1 mol% Cu/1.2 mol% BPhen, 4 equiv NFSI, 1 equiv B2pin2 instead of MeB(OH)2. d75 °C 1 mol% Cu/1.2 mol% BPhen, 4 equiv NFSI, 1 equiv B2pin2 instead of MeB(OH)2. eAcetone solvent.