Table 1:
Top TWAS results in IBD loci.
| Chr | base pairs | Phenotype | Significant genes in locus | Significant genes (P) |
|---|---|---|---|---|
| 5 | 130613600 | IBD | 1 | CDC42SE2 (2.3 × 10−12) |
| 6 | 167373547* | IBD | 1 | RNASET2 (2.6 × 10−12) |
| 5 | 150277909 | IBD | 1 | ZNF300P1 (5.8 × 10−11) |
| 3 | 49721532 | IBD | 2 | APEH (6.9 × 10−11), CAMKV (3.6 × 10−8) |
| 9 | 139266405 | IBD | 1 | SEC16A (1.8 × 10−10) |
| 5 | 131778452 | IBD | 4 | PDLIM4 (3.9 × 10−9), P4HA2 (9.2 × 10−9), LOC553103 (5.9 × 10−8), SLC22A5 (5.7 × 10−7) |
| 5 | 96252803* | IBD | 1 | ERAP2 (5.1 × 10−10) |
| 2 | 234173503* | CD | 1 | ATG16L1 (3.2 × 10−9) |
| 16 | 28517709* | IBD | 2 | APOBR (8.6 × 10−9), CCDC101 (1.0 × 10−7) |
| 10 | 35295431 | IBD | 1 | CUL2 (2.0 × 10−7) |
| 22 | 39659773 | IBD | 1 | PDGFB (3.7 × 10−7) |
| 1 | 155878732* | IBD | 1 | RIT1 (4.2 × 10−7) |
| 17 | 37912377* | IBD | 1 | GSDMB (5.6 × 10−7) |
| 1 | 159799910 | CD | 1 | KCNJ10 (5.9 × 10−6) |
| 1 | 160856964 | IBD | 1 | SLAMF7 (6.7 × 10−6) |
*
, locus also implicated in coloc analysis