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. Author manuscript; available in PMC: 2020 Aug 25.
Published in final edited form as: Genes Immun. 2019 Jan 29;20(7):577–588. doi: 10.1038/s41435-019-0059-y

Table 3:

Gene Prioritization Regression Model (GPRM) results

Estimate Standard Error t value P
Intercept 4.7 × 10−5 0.0011 0.042 0.97
Gene Level CD association (p < 3 × 10−6) 0.13 0.0049 27.2 < 2.0 × 10−16
Gene Level CD association (3 × 10−6 < p <0.05) 0.027 0.0018 15.2 < 2.0 × 10−16
WGCNA module (black) 0.023 0.0030 7.7 1.7 × 10−14
WGCNA module (green) −0.0069 0.0024 −2.9 0.0041
WGCNA module (greenyellow) −0.010 0.0040 −2.6 0.0097
WGCNA module (yellow) −0.0054 0.0024 −2.3 0.021
Differential expression M1/M2 0.012 0.0018 6.7 2.7 × 10−11
TWAS (8.3 × 10−6 < P < 0.05) 0.041 0.011 3.7 1.9 × 10−4
TWAS (P < 8.3 × 10−6) 0.0088 0.0046 1.9 0.057
Open chromatin Th17 cells 0.0022 0.0012 1.9 0.058

M1/M2, genes with higher expression in M1 compared to M2 in vitro differentiated macrophages