Table 3:
Associations between MRI features and Prolaris® relative risk.
| Reader 1 | Reader 2 | |||||||
|---|---|---|---|---|---|---|---|---|
| MRI Features | Prolaris® Relative Risk | p-Value | Prolaris® Relative Risk | p-Value | ||||
| Less Aggressive (n=33) | Consistent (n=57) | More Aggressive (n=28) | Less Aggressive (n=33) | Consistent (n=57) | More Aggressive (n=28) | |||
| PI-RADS v2 scores | 0.475 | 0.617 | ||||||
| 2 | 7 (21.2) | 10 (17.5) | 4 (14.3) | 8 (24.2) | 8 (14.0) | 4 (14.3) | ||
| 3 | 11 (33.3) | 12 (21.1) | 9 (32.1) | 12 (36.4) | 16 (28.1) | 10 (35.7) | ||
| 4 | 13 (39.4) | 30 (52.6) | 10 (35.7) | 12 (36.4) | 29 (50.9) | 11 (39.3) | ||
| 5 | 2 (6.1) | 5 (8.8) | 5 (17.9) | 1 (3.0) | 4 (7.0) | 3 (10.7) | ||
| Extracapsular Extension (%) | 3 (9.1) | 8 (14.0) | 9 (32.1) | 0.054 | 4 (12.1) | 8 (14.0) | 9 (32.1) | 0.300 |
| Median Tumor Length on T2w images (mm)[range] | 7.0 [0.0, 25.4] | 8.5 [0.0, 23.2] | 8.7 [0.0, 35.4] | 0.468 | 6.1 [0.0, 26.8] | 7.8 [0.0, 25.3] | 8.3 [0.0, 30.9] | 0.729 |
| Median Tumor Length on ADC maps (mm)[ [range] | 6.0 [0.0, 27.8] | 8.7 [0.0, 26.0] | 7.6 [0.0, 36.4] | 0.462 | 6.2 [0.0, 27.0] | 7.8 [0.0, 24.6] | 6.8 [0.0, 37.1] | 0.546 |
| Median Tumor Volume on ADC maps (cm3)[ [range] | 0.1 [0.0, 3.9] | 0.3 [0.0, 4.9] | 0.2 [0.0, 8.9] | 0.368 | 0.1 [0.0, 0.6] | 0.3 [0.0, 0.8] | 0.2 [0.0, 0.9] | 0.245 |
| Median Tumor ADC values (mm2/s) [range] | 1.2 [0.4, 1.9] | 1.0 [0.5, 2.5] | 1.0 [0.4, 1.9] | 0.223 | 1.2 [0.9, 1.5] | 0.9 [0.8, 1.5] | 1.0 [0.7, 1.5] | 0.491 |
| Median Tumor Volume with Markedly Restricted Diffusion (cm3) [range] | 0.0 [0.0, 3.5] | 0.1 [0.0, 3.3] | 0.0 [0.0, 7.5] | 0.287 | 0.0 [0.0, 0.2] | 0.10 [0.0, 0.5] | 0.10 [0.0, 0.5] | 0.144 |
Abbreviations: ADC Apparent Diffusion Coefficient, PI-RADSv2 Prostate Imaging Reporting and Data System version 2