Table 4:
Associations of MRI features and unfavorable findings on prostatectomy histopathology.
| Variable | No Adverse Feature (n=23) |
Any Adverse Feature (n=18) |
p-Value | ||||
| AUA Risk (%) | High | 0 (0.0) | 2 (11.1) | 0.161 | |||
| Intermediate | 13 (56.5) | 12 (66.7) | |||||
| Low | 10 (43.5) | 4 (22.2) | |||||
| Prolaris® Results | Median CCR score [range] | 3.1 [2.2, 5.5] | 3.8 [1.8, 4.7] | 0.049 | |||
| Relative Risk (%) | 0.311 | ||||||
| Less Aggressive | 6 (26.1) | 4 (22.2) | |||||
| Consistent | 12 (52.2) | 6 (33.3) | |||||
| More Aggressive | 5 (21.7) | 8 (44.4) | |||||
| Magnetic Resonance Imaging Features | Reader 1 | Reader 2 | |||||
| No | Any | p-Value | No | Any | p-Value | ||
| PI-RADSv2 scores (%) | 0.036 | 0.779 | |||||
| 2 | 2 (8.7) | 1 (5.6) | 3 (13.0) | 1 (5.6) | |||
| 3 | 6 (26.1) | 5 (27.8) | 7 (30.4) | 5 (27.8) | |||
| 4 | 15 (65.2) | 7 (38.9) | 12 (52.2) | 10 (55.6) | |||
| 5 | 0 (0) | 5 (27.8) | 1 (4.3) | 2 (11.1) | |||
| Extracapsular Extension (%) | 1 (4.3) | 9 (50.0) | 0.001 | 0 (0.0) | 9 (50.0) | <0.001 | |
| Median Tumor Length on T2w images (mm)[range] | 7.0 [0.0, 17.9] | 11.1 [0.0, 29.3] | 0.070 | 7.4 [0.0, 16.6] | 11.2 [0.0, 26.8] | 0.166 | |
| Median Tumor Length on ADC maps (mm)[ [range] | 7.5 [0.0, 18.0] | 11.6 [0.0, 28.1] | 0.052 | 7.3 [0.0, 17.2] | 10.6 [0.0, 27.0] | 0.201 | |
| Median Tumor Volume on ADC maps (cm3)[ [range] | 0.28 [0.0. 3.51] | 0.54 [0.0, 3.28] | 0.293 | 0.26 [0.0, 3.38] | 0.60 [0.0, 3.67] | 0.253 | |
| Median Tumor ADC values (mm2/s) [range] | 1.04 [0.6, 1.73] | 0.89 [0.42, 1.87] | 0.331 | 0.94 [0.58, 1.9] | 0.95 [0.42, 1.88] | 0.854 | |
| Median Tumor Volume with Markedly Restricted Diffusion (cm3) [range] | 0.07 [0.0, 2.26] | 0.21 [0.0, 2.88] | 0.125 | 0.10 [0.0, 2.23] | 0.15 [0.0, 3.25] | 0.255 | |
Abbreviations: ADC Apparent Diffusion Coefficient, AUA American Urologic Association, CCR Cell Cycle Risk, PI-RADSv2 Prostate Imaging Reporting and Data System version 2