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. 2020 Aug 25;20:261. doi: 10.1186/s12906-020-03055-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The levels of MEK1/2, p-MEK1/2, MKK4, p-MKK4, ICAM1 and VCAM1 in the rat synovium tissue. The areal densities of MEK1/2, p-MEK1/2, MKK4, p-MKK4, ICAM1 and VCAM1-positive cells in full image were calculated by Motic Med 6.0 Digital Medical Image Analysis System. Data represent the mean SE of each group (n = 10). ^#p < 0.05 vs control group, ^##p < 0.01 (independent samples t-test), ^*p < 0.05 vs model group; ^**p < 0.01 vs model group (one-way ANOVA followed by Dunnett’s t-test)