Table 3.
The association between hyperthyroidism and mammographic density among KARMA women without a cancer diagnosis (n = 51,928)
| No | Yes | OR (95% CI) | |||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||
| Mammographic density | |||||
| Q1 | 12,797 | 186 | 1.00 (REF) | 1.00 (REF) | 1.00 (REF) |
| Q2 | 12,801 | 182 | 0.98 (0.80–1.20) | 1.10 (0.89–1.36) | 1.09 (0.88–1.35) |
| Q3 | 12,807 | 174 | 0.94 (0.76–1.15) | 1.17 (0.93–1.48) | 1.16 (0.92–1.47) |
| Q4 | 12,825 | 156 | 0.84 (0.68–1.04) | 1.15 (0.88–1.51) | 1.14 (0.87–1.49) |
| Pfor square root continuous | 0.13 | 0.13 | 0.20 | ||
Model 1 is the univariate model. Model 2 adjusted for age and BMI. Model 3 further adjusted for age at menarche, number of births, family history of breast cancer, hormone replacement therapy use, oral contraceptive use, and benign breast disease