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. 2020 Aug 25;19:130. doi: 10.1186/s12943-020-01249-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Aberrant expression of METTL 3-METTL14 complex in pancreatic cancer. a Real-time PCR analysis of the relative mRNA levels of METTL3, METTL14, and WTAP in 20 paired pancreatic cancer tissues. * p < 0.05. b Quantification of western blot analyses of METTL3, METTL14, and WTAP levels in pancreatic cancer and adjacent tissues. * p < 0.05; ** p < 0.01. c Immunohistochemical analysis of METTL3/METTL14/WTAP expression in pancreatic cancer tissues; Kaplan-Meier analysis of the correlation between METTL3/METTL14/WTAP expression and the overall survival of pancreatic cancer patients; and relative METTL3/METTL14/WTAP expression scores in pancreatic cancer tissues per clinical and pathological stage. * p < 0.05; ***p < 0.001; n.s., no significance. d Colorimetric quantification of m⁶A in PANC-1 cells after METTL3 and METTL14 knockdown or overexpression. ** p < 0.01; ***p < 0.001