Table 1.
Association analysis of urolithiasis risk and SPP1 genetic variants considering their allelic and genotypic frequencies
| SPP1 genetic variants | Genotype/Allele | Urolithiasis patients n = 235, n (%) |
Healthy controls n = 243, n (%) |
OR (95% CI) | p-value (corrected)† |
|---|---|---|---|---|---|
| rs2853744:G > T | T/T | 07 (3.1%) | 21 (9.1%) | Referent | 0.024 |
| G/T | 61 (27.2%) | 62 (26.8%) | 2.95 (1.17–7.45) | ||
| G/G | 156 (69.6%) | 148 (64.1%) | 3.16 (1.31–7.66) | ||
| T | 75 (17%) | 104 (23%) | Referent | 0.035 | |
| G | 373 (83%) | 358 (77%) | 1.44 (1.03–2.01) | ||
| rs11730582:T > C | T/T | 63 (28%) | 69 (29.6%) | Referent | 0.017 |
| T/C | 87 (38.7%) | 113 (48.5%) | 0.84 (0.54–1.31) | ||
| C/C | 75 (33.3%) | 51 (21.9%) | 1.61 (0.98–2.64) | ||
| T | 213 (47%) | 251 (54%) | Referent | 0.056 | |
| C | 237 (53%) | 215 (46%) | 1.29 (1.00–1.68) | ||
| rs11439060:delG > G | G/G | 19 (8.3%) | 12 (5%) | Referent | 0.002 |
| G/dG | 65 (28.5%) | 103 (43.3%) | 0.40 (0.18–0.88) | ||
| dG/dG | 144 (63.2%) | 123 (51.7%) | 0.74 (0.35–1.58) | ||
| G | 103 (23%) | 127 (27%) | Referent | 0.170 | |
| dG | 353 (77%) | 349 (73%) | 1.24 (0.92–1.68) |
†p-values are corrected for age and gender. p-value adjustment for multiple testing using Bonferroni method was also made (p-value threshold 0.016). Statistical significance is highlighted in bold
OR Odds ratio; n (%), frequency and CI Confidence interval