Table 2.
Association analysis of urolithiasis risk and SPP1 genetic variants considering dominant, recessive and log-additive genetic models
| SPP1 polymorphisms | Model | Genotypes | Patients n = 235, n (%) | Controls value 243, n (%) | OR (95% CI) | p-value (corrected)† |
|---|---|---|---|---|---|---|
| rs2853744:G > T | Dominant | T/T | 07 (3.1%) | 21 (9.1%) | 1.00 | 0.006 |
| G/T-G/G | 217 (96.9%) | 210 (90.9%) | 3.14 (1.29–7.45) | |||
| Recessive | T/T-G/T | 68 (30.4%) | 83 (35.1%) | 1.00 | 0.210 | |
| G/G | 156 (69.4%) | 148 (64.9%) | 1.29 (0.87–1.90) | |||
| Log-additive | – | – | – | 1.38 (1.01–1.89)S | 0.040 | |
| rs11730582:T > C | Dominant | T/T | 63 (28%) | 69 (29.6%) | 1.00 | 0.700 |
| T/C-C/C | 162 (72%) | 164 (70.4%) | 1.08 (0.72–1.62) | |||
| Recessive | T/T-T/C | 150 (66.7%) | 182 (78.1%) | 1.00 | 0.006 | |
| C/C | 75 (33.3%) | 51 (21.9%) | 1.78 (1.18–2.71) | |||
| Log-additive | – | – | – | 1.26 (0.99–1.61) | 0.062 | |
| rs11439060:delG > G | Dominant | G/G | 19 (8.3%) | 12 (5%) | 1.00 | 0.150 |
| dG/G-dG/dG | 209 (91.7%) | 226 (95%) | 0.58 (0.28–1.23) | |||
| Recessive | G/G-dG/G | 84 (36.8%) | 115 (48.3%) | 1.00 | 0.012 | |
| dG/dG | 144 (63.2%) | 123 (51.7%) | 1.60 (1.11–2.60) | |||
| Log-additive | – | – | – | 1.24 (0.92–1.67) | 0.15 |
†p-values are corrected for age and gender. p-value adjustment for multiple testing using Bonferroni method was also made (p-value threshold 0.016). Statistical significance is highlighted in bold
OR Odds ratio; n (%), frequency and CI Confidence interval