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. 2020 Aug 25;39:168. doi: 10.1186/s13046-020-01673-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CREB5 is upregulated in CRC and associated with a poor prognosis. a and b Real-time PCR and western blotting analysis of CREB5 expression in paired human colon cancer tissues and adjacent noncancerous tissues (p < 0.01). Quantity One software was used to quantify the protein expression levels. c IHC representative images of CREB5 expression in normal intestinal epithelium and CRC tissues. Scale bar: 50 μm. d The paraffin samples of 198 CRC patients were divided into a low-CREB5 expression group (n = 108) and a high-CREB5 expression group (n = 90) based on IHC results. The Kaplan-Meier method was used to analyse survival curves, and the log-rank test was used to compare differences (p = 0.023)